(3S)-3-{[(tert-Butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid
Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid
CAS: 922178-94-7
Molecular Formula: C15H18F3NO4
(3S)-3-{[(tert-Butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid - Names and Identifiers
(3S)-3-{[(tert-Butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid - Physico-chemical Properties
| Molecular Formula | C15H18F3NO4 |
| Molar Mass | 333.3 |
| Density | 1.292 |
| Melting Point | 123 - 125°C |
| Boling Point | 443.1±45.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 4.30±0.10(Predicted) |
| Storage Condition | 2-8°C |
(3S)-3-{[(tert-Butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid - Introduction
Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid is an organic compound with the following properties:
1. Appearance: White crystalline solid.
2. solubility: can be dissolved in some organic solvents, such as chloroform, ether and dimethylformamide.
3. Melting point: about 80-85°C.
4. Density: about 1.348 g/mL.
5. chemical properties: belongs to a kind of amino acid derivatives containing protecting group.
Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid mainly includes:
1. photosensitizer: in the preparation of photosensitive materials, it can be used as one of the raw materials of photosensitizer.
2. Drug intermediates: intermediates that can be used to synthesize drugs and bioactive molecules.
3. reagent: in the field of organic synthesis and medicine, can be used as the raw material of reagent.
the method for preparing Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid is relatively complicated, and the specific steps are as follows:
1. Add L-glutamyl bromide dropwise to the target compound in an appropriate solution.
2. Add dimethylformamide solution and control the reaction by the corresponding temperature.
3. Add the appropriate amount of alkali to promote the completion of the reaction.
4. Boc-hydrazone was added to form the desired product.
5. Further crystallization and purification were carried out to obtain the final product.
Regarding the safety information of Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid, the following matters need to be noted:
1. The compound may be irritating to the eyes, skin and respiratory system, so it is necessary to wear appropriate protective equipment during operation, such as gloves, glasses and protective masks.
2. Avoid inhaling the dust or gas of the compound. If you inhale it accidentally, you should immediately move to a well-ventilated place and seek medical help if necessary.
3. When using the compound, good laboratory practices should be followed to ensure safety and operability.
1. Appearance: White crystalline solid.
2. solubility: can be dissolved in some organic solvents, such as chloroform, ether and dimethylformamide.
3. Melting point: about 80-85°C.
4. Density: about 1.348 g/mL.
5. chemical properties: belongs to a kind of amino acid derivatives containing protecting group.
Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid mainly includes:
1. photosensitizer: in the preparation of photosensitive materials, it can be used as one of the raw materials of photosensitizer.
2. Drug intermediates: intermediates that can be used to synthesize drugs and bioactive molecules.
3. reagent: in the field of organic synthesis and medicine, can be used as the raw material of reagent.
the method for preparing Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid is relatively complicated, and the specific steps are as follows:
1. Add L-glutamyl bromide dropwise to the target compound in an appropriate solution.
2. Add dimethylformamide solution and control the reaction by the corresponding temperature.
3. Add the appropriate amount of alkali to promote the completion of the reaction.
4. Boc-hydrazone was added to form the desired product.
5. Further crystallization and purification were carried out to obtain the final product.
Regarding the safety information of Boc-(S)-3-Amino-4-(2,4,5-Trifluorophenyl)-butyric acid, the following matters need to be noted:
1. The compound may be irritating to the eyes, skin and respiratory system, so it is necessary to wear appropriate protective equipment during operation, such as gloves, glasses and protective masks.
2. Avoid inhaling the dust or gas of the compound. If you inhale it accidentally, you should immediately move to a well-ventilated place and seek medical help if necessary.
3. When using the compound, good laboratory practices should be followed to ensure safety and operability.
Last Update：2024-04-09 21:21:28
![(3S)-3-{[(tert-Butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid](http://res.chembk.com/assets/images/structure/922178-94-7.gif)
Supplier List
Spot supply
Product Name: Sitagliptin Impurity 11 Visit Supplier Webpage Request for quotationCAS: 922178-94-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Visit Supplier Webpage Request for quotation
CAS: 922178-94-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 922178-94-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Sitagliptin Impurity 11 Visit Supplier Webpage Request for quotationCAS: 922178-94-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID Visit Supplier Webpage Request for quotation
CAS: 922178-94-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 922178-94-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
(3S)-3-{[(tert-Butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid
O-Desmorpholinopropyl Gefitinib
O-Desmorpholinopropyl Gefitinib